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Curr Opin Immunol. 2005 Jun;17(3):290-7.

The role of CD22 and other inhibitory co-receptors in B-cell activation.

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  • 1Department of Genetics, University of Erlangen, Staudtstrasse 5, 91058 Erlangen, Germany.


Inhibitory co-receptors downmodulate B-cell receptor (BCR) signalling by setting a signalling threshold that prevents overstimulation of B cells. Activation of these inhibitory co-receptors occurs by phosphorylation on their cytoplasmic inhibitory immunoreceptor tyrosine-based inhibition motifs (ITIMs), followed by recruitment of the tyrosine phosphatase SHP-1 or the lipid phosphatase SHIP, and depends on their association with the BCR. Recent evidence shows that B-cell signal inhibition is regulated by ligand binding of inhibitory receptors.

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