Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neurobiol. 2005 Jul;64(1):47-57.

Dendritic spine morphogenesis and plasticity.

Author information

  • 1Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.

Abstract

Dendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts. Recent studies have illuminated the numerous molecules regulating spine development, many of which converge on the regulation of actin filaments. In addition, interactions with glial cells are emerging as important regulators of spine morphology. In many cases, spine morphogenesis, plasticity, and maintenance also depend on synaptic activity, as shown by recent studies demonstrating changes in spine dynamics and maintenance with altered sensory experience.

Copyright 2005 Wiley Periodicals, Inc.

PMID:
15884005
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk