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Fam Cancer. 2005;4(1):9-12.

SDHC mutations in hereditary paraganglioma/pheochromocytoma.

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  • 1Ulrich Müller, Institut für Humangenetik, Justus-Liebig-Universität, Giessen, Schlangenzahl 14, Germany.


Mutations in genes coding for three of the four components of mitochondrial complex II can cause paragangliomas (PGLs)/pheochromocytomas. The three genes include SDHB, -C, and -D. SDHC and SDHD anchor the catalytic subunits SDHA and -B of mitochondrial complex II in the inner mitochondrial membrane. SDHD is maternally imprinted but SDHB and -C are not. While SDHD and -- to a lesser degree -- SDHB mutations have been found in many cases of hereditary PGL, SDHC mutations are rare. This article reviews the SDHC mutations described to date and discusses possible mechanisms of tumorigenesis.

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