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    Neurology. 2005 May 10;64(9):1618-20.

    Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients.

    Source

    Department of Neurological and Visual Sciences, University of Verona, Verona, Italy.

    Abstract

    The authors describe 12 neuroleptic-treated patients with dementia of various etiologies who showed CSF elevation of phosphorylated 14-3-3zeta and normal tau protein levels. This contrasted with elevated amounts of 14-3-3 gamma, epsilon, and unphosphorylated zeta coupled to high tau protein levels in Creutzfeldt-Jakob disease and negative 14-3-3 assay in drug-free patients with dementia. Characterization of CSF 14-3-3 isoforms and determination of tau protein level can help to distinguish different etiologies of dementia.

    PMID:
    15883327
    [PubMed - indexed for MEDLINE]

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