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J Cell Biol. 2005 May 9;169(3):391-7.

MCAK associates with the tips of polymerizing microtubules.

Author information

  • 1Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA.

Abstract

MCAK is a member of the kinesin-13 family of microtubule (MT)-depolymerizing kinesins. We show that the potent MT depolymerizer MCAK tracks (treadmills) with the tips of polymerizing MTs in living cells. Tip tracking of MCAK is inhibited by phosphorylation and is dependent on the extreme COOH-terminal tail of MCAK. Tip tracking is not essential for MCAK's MT-depolymerizing activity. We propose that tip tracking is a mechanism by which MCAK is preferentially localized to regions of the cell that modulate the plus ends of MTs.

PMID:
15883193
[PubMed - indexed for MEDLINE]
PMCID:
PMC2171944
Free PMC Article

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