Kidney Int. 2005 Jun;67(6):2101-13.

Preeclampsia: a renal perspective.

Karumanchi SA, Maynard SE, Stillman IE, Epstein FH, Sukhatme VP.

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Renal Division and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. sananth@bidmc.harvard.edu

Abstract

Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenesis of proteinuria and hypertension of preeclampsia.

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