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Genetica. 2005 Feb;123(1-2):3-13.

Theories of adaptation: what they do and don't say.

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  • 1Department of Biology, University of Rochester, Rochester, NY 14627, USA. aorr@mail.rochester.edu

Abstract

Theoretical work on adaptation has lagged behind experimental. But two classes of adaptation model have been partly explored. One is phenotypic and the other DNA sequence based. I briefly consider an example of each--Fisher's geometric model and Gillespie's mutational landscape model, respectively--reviewing recent results. Despite their fundamental differences, these models give rise to several strikingly similar results. I consider possible reasons for this congruence. I also emphasize what predictions do and, as important, do not follow from these models.

PMID:
15881676
[PubMed - indexed for MEDLINE]
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