Display Settings:

Format

Send to:

Choose Destination
    J Biol Chem. 2005 Jul 8;280(27):25840-8. Epub 2005 May 6.

    A cryptic Rab1-binding site in the p115 tethering protein.

    Source

    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA.

    Erratum in

    • J Biol Chem. 2006 Sep 22;281(38):28488.

    Abstract

    Small GTPases and coiled-coil proteins of the golgin family help to tether COPI vesicles to Golgi membranes. At the cis-side of the Golgi, the Rab1 GTPase binds directly to each of three coiled-coil proteins: p115, GM130, and as now shown, Giantin. Rab1 binds to a coiled-coil region within the tail domain of p115 and this binding is inhibited by the C-terminal, acidic domain of p115. Furthermore, GM130 and Giantin bind to the acidic domain of p115 and stimulate p115 binding to Rab1, suggesting that p115 binding to Rab1 is regulated. Regulation of this interaction by proteins such as GM130 and Giantin may control the membrane recruitment of p115 by Rab1.

    PMID:
    15878873
    [PubMed - indexed for MEDLINE]
    Free full text

      Supplemental Content

      Icon for HighWire Press

      Save items

      loading

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk