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Nat Biotechnol. 2005 May;23(5):567-75.

Baculovirus as versatile vectors for protein expression in insect and mammalian cells.

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  • 1Gene Expression Protein Biochemistry, GlaxoSmithKline R&D, 5 Moore Drive, Research Triangle Park, North Carolina 27709, USA. <>


Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to membrane-bound proteins, have been successfully produced in baculovirus-infected insect cells. Yet, in addition to its value in producing recombinant proteins in insect cells and larvae, this viral vector system continues to evolve in new and unexpected ways. This is exemplified by the development of engineered insect cell lines to mimic mammalian cell glycosylation of expressed proteins, baculovirus display strategies and the application of the virus as a mammalian-cell gene delivery vector. Novel vector design and cell engineering approaches will serve to further enhance the value of baculovirus technology.

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