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Org Lett. 2005 May 12;7(10):1967-9.

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

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  • 1Institute of Biomolecular Chemistry, Chemical Research Center of Hungarian Academy of Sciences, Budapest.

Abstract

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

PMID:
15876031
[PubMed - indexed for MEDLINE]
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