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Indian J Exp Biol. 2005 Apr;43(4):351-5.

Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.

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  • 1Department of Life Science, Selvamm Arts and Science College, Namakkal, India. pgsvedhakumar@yahoo.com

Abstract

Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.

PMID:
15875720
[PubMed - indexed for MEDLINE]
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