Twenty-four hour tolbutamide plasma concentration as a phenotypic measure of CYP2C9 activity

Eur J Clin Pharmacol. 2005 Jun;61(4):315-6. doi: 10.1007/s00228-005-0922-9. Epub 2005 May 4.
No abstract available

Publication types

  • Comment
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Cytochrome P-450 CYP2C9
  • Genotype
  • Humans
  • Hypoglycemic Agents
  • Pharmacogenetics / methods
  • Phenotype
  • Time Factors
  • Tolbutamide / blood
  • Tolbutamide / pharmacokinetics*

Substances

  • Hypoglycemic Agents
  • Tolbutamide
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases