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J Pediatr Psychol. 2006 Apr;31(3):262-71. Epub 2005 May 4.

The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis.

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  • 1Department of Psychology, Texas Scottish Rite Hospital for Children, 2222 Welborn, Dallas, Texas 75219, USA.



To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA).


Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information.


Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects.


These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.

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