Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
BMJ. 1992 Apr 18;304(6833):1015-9.

Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up.

Author information

  • 1Medical Hospital and Research Centre, Moradabad, India.

Abstract

OBJECTIVE:

To test whether a fat reduced diet rich in soluble dietary fibre, antioxidant vitamins, and minerals reduces complications and mortality after acute myocardial infarction.

DESIGN:

Randomised, single blind, controlled trial.

SETTING:

Primary and secondary care research centre for patients with myocardial infarction.

SUBJECTS:

505 patients with suspected acute myocardial infarction. Those with definite or possible acute myocardial infarction and unstable angina based on World Health Organisation criteria were assigned to diet A (n = 204) or diet B (n = 202) within 24-48 hours of infarction.

INTERVENTIONS:

Both groups were advised to follow a fat reduced diet. Group A was also advised to eat more fruit, vegetables, nuts, and grain products.

MAIN OUTCOME MEASURES:

Mortality from cardiac disease and other causes. Serum lipid concentrations and compliance with diet.

RESULTS:

Blood lipoprotein concentrations and body weight fell significantly in patients in group A compared with those in group B (cholesterol fell by 0.74 mmol/l in group A v 0.32 mmol/l in group B, 95% confidence interval of difference 0.14 to 0.70, and weight by 7.1 v 3.0 kg, 0.52 to 7.68). The incidence of cardiac events was significantly lower in group A than group B (50 v 82 patients, p less than 0.001). Group A also had lower total mortality (21 v 38 died, p less than 0.01) than group B.

CONCLUSIONS:

Comprehensive dietary changes in conjunction with weight loss immediately after acute myocardial infarction may modulate blood lipoproteins and significantly reduce complications and mortality after one year.

Comment in

PMID:
1586782
[PubMed - indexed for MEDLINE]
PMCID:
PMC1881705
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk