J Nutr. 2005 May;135(5):1320-5.

Regulation of ghrelin in physiologic and pathophysiologic states.

Source

Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104, USA. dianalw@u.washington.edu

Abstract

Ghrelin, a ligand for the growth hormone secretagogue receptor, is an orexigenic hormone produced in the gastrointestinal tract. In humans and other animals, circulating ghrelin levels fluctuate over the course of the day in relation to food intake. If circulating ghrelin plays a role in determining food intake from meal to meal, it will be important to understand the factors that regulate plasma ghrelin levels in relation to feeding. Circulating ghrelin levels also appear to reflect body weight changes over the longer term, raising the possibility that ghrelin functions as an adiposity signal. This review discusses some of the factors known to affect ghrelin levels, including nutrient stimulation of the gastrointestinal tract, diet composition, and weight loss. We also consider potential hormonal and neural mediators of the effects of nutrients and weight change on ghrelin levels.

PMID:: 15867333; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Ghrelin: update 2003. [Nutr Rev. 2003]
Review Ghrelin: update 2003.
Eisenstein J, Greenberg A. Nutr Rev. 2003 Mar; 61(3):101-4.
Review Ghrelin and the short- and long-term regulation of appetite and body weight. [Physiol Behav. 2006]
Review Ghrelin and the short- and long-term regulation of appetite and body weight.
Cummings DE. Physiol Behav. 2006 Aug 30; 89(1):71-84. Epub 2006 Jul 21.
Review The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. [Obes Rev. 2007]
Review The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review.
Klok MD, Jakobsdottir S, Drent ML. Obes Rev. 2007 Jan; 8(1):21-34.
Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss. [Int J Obes Relat Metab Disord....]
Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss.
Perreault M, Istrate N, Wang L, Nichols AJ, Tozzo E, Stricker-Krongrad A. Int J Obes Relat Metab Disord. 2004 Jul; 28(7):879-85.
Review Effects of ghrelin on food intake and neuroendocrine function in sheep. [Anim Reprod Sci. 2004]
Review Effects of ghrelin on food intake and neuroendocrine function in sheep.
Sugino T, Hasegawa Y, Kurose Y, Kojima M, Kangawa K, Terashima Y. Anim Reprod Sci. 2004 Jul; 82-83:183-94.

See reviews... See all...

Cited by 13 PubMed Central articles

Review Anorexia nervosa: a unified neurological perspective. [Int J Med Sci. 2011]
Review Anorexia nervosa: a unified neurological perspective.
Hasan TF, Hasan H. Int J Med Sci. 2011; 8(8):679-703. Epub 2011 Oct 22.
The hungry stomach: physiology, disease, and drug development opportunities. [Front Pharmacol. 2010]
The hungry stomach: physiology, disease, and drug development opportunities.
Sanger GJ, Hellström PM, Näslund E. Front Pharmacol. 2010; 1:145. Epub 2011 Feb 18.
Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. [J Cachexia Sarcopenia Muscle. ...]
Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia.
Müller TD, Perez-Tilve D, Tong J, Pfluger PT, Tschöp MH. J Cachexia Sarcopenia Muscle. 2010 Dec; 1(2):159-167. Epub 2010 Dec 17.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation of ghrelin in physiologic and pathophysiologic states.
Regulation of ghrelin in physiologic and pathophysiologic states.
J Nutr. 2005 May ;135(5):1320-5.

PubMed
Aerobic exercise training decreases leucine oxidation at rest in healthy adults.
Aerobic exercise training decreases leucine oxidation at rest in healthy adults.
J Nutr. 2005 May ;135(5):1088-92.

PubMed
Nutritional, dietary and postprandial oxidative stress.
Nutritional, dietary and postprandial oxidative stress.
J Nutr. 2005 May ;135(5):969-72.

PubMed
Molecular abnormalities of a phosphoglycerate kinase variant generated by sponta...
Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation.
Blood. 1992 May 15 ;79(10):2759-62.

PubMed
Serum human telomerase reverse transcriptase messenger RNA as a novel tumor mark...
Serum human telomerase reverse transcriptase messenger RNA as a novel tumor marker for hepatocellular carcinoma.
Clin Cancer Res. 2005 May 1 ;11(9):3205-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: