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J Exp Med. 2005 May 2;201(9):1355-9.

Blocking IL-1 in systemic inflammation.

Author information

  • 1Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA. cdinare333@aol.com

Abstract

A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1beta might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.

PMID:
15867089
[PubMed - indexed for MEDLINE]
PMCID:
PMC2213199
Free PMC Article
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