Vet Microbiol. 2005 May 20;107(3-4):307-12.

Role of HdeA in acid resistance and virulence in Brucella abortus 2308.

Valderas MW, Alcantara RB, Baumgartner JE, Bellaire BH, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM 2nd.

Source

Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27834, USA.

Abstract

Two-dimensional gel electrophoretic analysis of cell lysates suggests that stationary phase production of wild-type levels of an ortholog of the low pH dependent chaperone HdeA in Brucella abortus 2308 during growth in a minimal medium requires the presence of the RNA binding protein Hfq. Although mutational analysis demonstrated that HdeA contributes to acid resistance in this bacterium, this protein is not required for wild-type virulence in the BALB/c mouse model. These experimental findings indicate that the brucellae rely upon additional gene products to resist the acidic conditions they encounter in the phagosomal compartment of host macrophages.

PMID:: 15863292; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in mice. [Mol Microbiol. 1999]
The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in mice.
Robertson GT, Roop RM Jr. Mol Microbiol. 1999 Nov; 34(4):690-700.
The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice. [Infect Immun. 2005]
The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice.
Gee JM, Valderas MW, Kovach ME, Grippe VK, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM 2nd. Infect Immun. 2005 May; 73(5):2873-80.
The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice. [Mol Microbiol. 2000]
The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice.
Robertson GT, Kovach ME, Allen CA, Ficht TA, Roop RM 2nd. Mol Microbiol. 2000 Feb; 35(3):577-88.
Review Brucella stationary-phase gene expression and virulence. [Annu Rev Microbiol. 2003]
Review Brucella stationary-phase gene expression and virulence.
Roop RM 2nd, Gee JM, Robertson GT, Richardson JM, Ng WL, Winkler ME. Annu Rev Microbiol. 2003; 57:57-76. Epub 2003 May 1.
Review Seeking a niche: putative contributions of the hfq and bacA gene products to the successful adaptation of the brucellae to their intracellular home. [Vet Microbiol. 2002]
Review Seeking a niche: putative contributions of the hfq and bacA gene products to the successful adaptation of the brucellae to their intracellular home.
Roop RM 2nd, Robertson GT, Ferguson GP, Milford LE, Winkler ME, Walker GC. Vet Microbiol. 2002 Dec 20; 90(1-4):349-63.

See reviews... See all...

Cited by 2 PubMed Central articles

Comparative study of the roles of AhpC and KatE as respiratory antioxidants in Brucella abortus 2308. [J Bacteriol. 2010]
Comparative study of the roles of AhpC and KatE as respiratory antioxidants in Brucella abortus 2308.
Steele KH, Baumgartner JE, Valderas MW, Roop RM 2nd. J Bacteriol. 2010 Oct; 192(19):4912-22. Epub 2010 Jul 30.
Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome. [BMC Genomics. 2010]
Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome.
Lamontagne J, Béland M, Forest A, Côté-Martin A, Nassif N, Tomaki F, Moriyón I, Moreno E, Paramithiotis E. BMC Genomics. 2010 May 12; 11:300. Epub 2010 May 12.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Role of HdeA in acid resistance and virulence in Brucella abortus 2308.
Role of HdeA in acid resistance and virulence in Brucella abortus 2308.
Vet Microbiol. 2005 May 20 ;107(3-4):307-12.

PubMed
Rituximab therapy of lymphoma is enhanced by orally administered (1-->3),(1-->4)...
Rituximab therapy of lymphoma is enhanced by orally administered (1-->3),(1-->4)-D-beta-glucan.
Leuk Res. 2005 Jun ;29(6):679-83.

PubMed
Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hered...
Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations.
Gynecol Oncol. 2005 May ;97(2):457-67.

PubMed
Influence of spine morphology on intervertebral disc loads and stresses in asymp...
Influence of spine morphology on intervertebral disc loads and stresses in asymptomatic adults: implications for the ideal spine.
Spine J. 2005 May-Jun ;5(3):297-309.

PubMed
Neurobehavioral probes for physiologic neuroimaging studies.
Neurobehavioral probes for physiologic neuroimaging studies.
Arch Gen Psychiatry. 1992 May ;49(5):409-14.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Role of HdeA in acid resistance and virulence in Brucella abortus 2308.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information