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Am J Ophthalmol. 2005 May;139(5):802-6.

Relation between reduction of foveal thickness and visual acuity in diabetic macular edema treated with intravitreal triamcinolone.

Author information

  • 1Department of Clinical Ophthalmology, Save Sight Institute, University of Sydney, GPO Box 4337, Sydney, NSW 2001, Australia. jorgen@eye.usyd.edu.au

Abstract

PURPOSE:

To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema.

DESIGN:

Prospective, interventional, nonrandomized clinical trial.

METHOD:

Patients: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. Main Outcome Measures: Best-corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment.

RESULTS:

At baseline the average foveal thickness was 462 +/- 154 microm (95% confidence interval, 397-527 microm) and at 3 months 257 +/-114 microm (95% confidence interval, 209-305 microm) (P < .0001). The best-corrected logMAR average visual acuity was 60.5 +/- 10.5 (95% confidence interval, 56.0-65.0) ETDRS letters at baseline compared with 65.5 +/- 11.1 (95% confidence interval, 60.8-70.1) 3 months after the injection (P = .0001). There was no correlation between the improvement in visual acuity and the reduction of foveal thickness (r = 0.054, P = .8), but there was a correlation between reduction in foveal thickness and the age of the patients (r = 0.53, P = .008).

CONCLUSION:

A single injection of 4 mg of intravitreal triamcinolone acetonide effectively reduces the foveal thickness in diabetic macular edema and improves visual acuity, but there does not appear to be a strong correlation between the reduction of foveal thickness and the improvement in visual acuity.

PMID:
15860283
[PubMed - indexed for MEDLINE]
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