Send to:

Choose Destination
See comment in PubMed Commons below
Eur Heart J. 2005 Sep;26(17):1700-4. Epub 2005 Apr 26.

Dendritic cells in atherosclerosis: current status of the problem and clinical relevance.

Author information

  • 1Surgical Professorial Unit, Level 5, DeLacy Building, St Vincent's Hospital Sydney, University of New South Wales, Darlinghurst, New South Wales 2010, Australia.


Dendritic cells (DCs) are the most potent antigen-presenting cells. DCs were identified in arteries in 1995 and, since then, further knowledge has been gained indicating the importance of DCs in atherosclerosis. Vascular DCs have been shown to become activated from a very early stage of atherosclerosis. Some DCs cluster with T cells directly within atherosclerotic lesions, while others migrate to lymphoid organs to activate T cells. Dyslipidaemia systemically alters DC function and recent findings suggest that DCs play a role in plaque destabilization. This review summarizes the current status of the problem.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk