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Curr Biol. 2005 Apr 26;15(8):743-9.

RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus.

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  • 1Department of Genetics, Faculty of Veterinary Medicine, University of Liège, Belgium.

Erratum in

  • Curr Biol. 2005 May 10;15(9):884.


The Dlk1-Gtl2 imprinted domain, encompassing the callipyge (CLPG) locus in sheep, has recently been shown to harbor a large number of maternally expressed miRNA genes [1, 2]. Two of these (mir127 and mir136) are processed from a transcript (antiPeg11) that is antisense to Rtl1/Peg11, a paternally expressed intronless gene with homology to the gag and pol polyproteins of Sushi-like retroelements [3]. We herein demonstrate that several additional miRNAs are processed from antiPeg11 and that these regulate Rtl1/Peg11 in trans by guiding RISC-mediated cleavage of its mRNA. This is the first demonstration of miRNA-mediated RNAi involving imprinted genes in mammals.

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