Curr Biol. 2005 Apr 26;15(8):R305-8.

Actin nucleation: spire - actin nucleator in a class of its own.

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Ludwig Institute for Cancer Research, UCL Branch, London, UK. buzz@ludwig.ucl.ac.uk

Abstract

The rate limiting step for actin filament polymerisation is nucleation, and two types of nucleator have been described: the Arp2/3 complex and the formins. A recent study has now identified in Spire a third class of actin nucleator. The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation.

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Drosophila Spire is an actin nucleation factor. [Nature. 2005]
Drosophila Spire is an actin nucleation factor.
Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD. Nature. 2005 Jan 27; 433(7024):382-8.
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Actin nucleation: spire - actin nucleator in a class of its own.

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