Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Hum Brain Mapp. 2005 Jul;25(3):336-44.

Function of striatum beyond inhibition and execution of motor responses.

Author information

  • 1Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, Heidelberglaan Utrecht, The Netherlands. M.Vink@azu.nl

Abstract

We used functional magnetic resonance imaging (fMRI) to study the role of the striatum in inhibitory motor control. Subjects had to refrain from responding to designated items (STOP trials) within a similar series of motor stimuli. Striatal activation was increased significantly compared to that when responding to all targets within a series of motor stimuli, indicating that the striatum is more active when inhibitory motor control over responses is required. The likelihood of a STOP trial was varied parametrically by varying the number of GO trials before a STOP trial. We could thus measure the effect of expecting a STOP trial on the fMRI response in the striatum. We show for the first time in humans that the striatum becomes more active when the likelihood of inhibiting a planned motor response increases. Our findings suggest that the striatum is critically involved in inhibitory motor control, most likely by controlling the execution of planned motor responses.

PMID:
15852388
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk