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Nat Rev Mol Cell Biol. 2005 May;6(5):376-85.

MicroRNA biogenesis: coordinated cropping and dicing.

Author information

  • Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151-742, Korea. narrykim@snu.ac.kr

Abstract

The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.

PMID:
15852042
[PubMed - indexed for MEDLINE]
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