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Neurology. 2005 Apr 26;64(8):1431-4.

Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment.

Author information

  • 1Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA 94143-1207, USA. adam.boxer@memory.ucsf.edu

Abstract

An elevated serum homocysteine level is a risk factor for the development of cognitive impairment. Reported is a late-onset case of hyperhomocystinemia due to a vitamin B12 metabolic deficit (cobalamin C) with cognitive impairment, primarily in frontal/executive function. After homocysteine-lowering therapy, the patient's functional and neuropsychological status improved in conjunction with a decrease in leukoariosis on his MRI scan. These findings suggest that homocysteine-related cognitive impairment may be partially reversible.

PMID:
15851736
[PubMed - indexed for MEDLINE]
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