Proc Natl Acad Sci U S A. 2005 May 3;102 Suppl 1:6522-6. Epub 2005 Apr 25.

The genetic basis of reproductive isolation: insights from Drosophila.

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Department of Biology, University of Rochester, NY 14627, USA. aorr@mail.rochester.edu

Abstract

Recent studies of the genetics of speciation in Drosophila have focused on two problems: (i) identifying and characterizing the genes that cause reproductive isolation, and (ii) determining the evolutionary forces that drove the divergence of these "speciation genes." Here, I review this work. I conclude that speciation genes correspond to ordinary loci having normal functions within species. These genes fall into several functional classes, although a role in transcriptional regulation could prove particularly common. More important, speciation genes are typically very rapidly evolving, and this divergence is often driven by positive Darwinian selection. Finally, I review recent work in Drosophila pseudoobscura on the possible role of meiotic drive in the evolution of the genes that cause postzygotic isolation.

PMID:: 15851676; [PubMed - indexed for MEDLINE]
PMCID:: PMC1131866

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