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Chem Biol. 2005 Apr;12(4):409-10.

Biotin synthase: enzyme or reactant?

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  • 1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.


Biotin synthase catalyzes formation of a thiophane ring through a radical mechanism that is difficult to reconstitute in vitro. Choi-Rhee and Cronan measure a turnover of 20-60 equivalents of biotin in vivo, but also find that turnover renders the protein susceptible to proteolytic destruction.

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