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Vet Rec. 2005 Apr 23;156(17):538-42.

Effects of surgery on the acute phase response in clinically normal and diseased horses.

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  • 1Department of Veterinary Surgery, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland.


The serum concentrations of serum amyloid A, haptoglobin and fibrinogen were measured in a group of horses before and at intervals after elective and non-elective surgery, and in a control group of normal horses. There was a significant, rapid and repeatable increase in the concentration of serum amyloid A in response to both elective and non-elective surgery. In the control horses its serum concentration was within the normal range, from 0 to 0.2 microg/ml. Twenty-four hours after elective surgery its mean peak concentration was 16.4 microg/ml, and after non-elective surgery it was 27.3 microg/ml. In contrast, the serum concentrations of haptoglobin and fibrinogen increased more slowly after surgery and had not decreased by 72 hours after surgery.

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