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Chem Commun (Camb). 2005 Apr 28;(16):2101-3. Epub 2005 Mar 9.

Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection.

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  • 1Northwestern University and NIH, NIDDK, Laboratory of Bioorganic Chemistry, Bethesda, MD, USA.

Abstract

trans-Cyclopentane-modified PNA has been successfully utilized as a target capture strand to improve the detection limit of a known DNA detection assay, and provide high levels of mismatch discrimination.

PMID:
15846413
[PubMed - indexed for MEDLINE]
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