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Science. 2005 May 13;308(5724):1043-5. Epub 2005 Apr 21.

Obesity and metabolic syndrome in circadian Clock mutant mice.

Author information

  • 1Department of Neurology, Northwestern University, Evanston, IL 60208, USA.

Abstract

The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.

PMID:
15845877
[PubMed - indexed for MEDLINE]
PMCID:
PMC3764501
Free PMC Article

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