Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd., Gainesville, FL 32610-0424, USA.
Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.