University of North Carolina, Department of Pharmacology, School of Medicine, Chapel Hill, NC 27599, USA. arjay@med.unc.edu
Conjugation of oligonucleotides to certain types of peptides provides an interesting approach for enhancing delivery of antisense and siRNA to cells and tissues. This article will provide a perspective on issues in oligonucleotide delivery, and will examine recent literature on the preparation and use of several types of peptide-oligonucleotide conjugates.