Determination of ambroxol in an automated multi-pumping pulsed flow system

Anal Sci. 2005 Apr;21(4):461-4. doi: 10.2116/analsci.21.461.

Abstract

A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg l(-1) (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min(-1), sample volume = 80 microl).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ambroxol / analysis*
  • Calibration
  • Expectorants / analysis*
  • Flow Injection Analysis
  • Hydrogen-Ion Concentration
  • Indicators and Reagents
  • Solutions

Substances

  • Expectorants
  • Indicators and Reagents
  • Solutions
  • Ambroxol