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PLoS Med. 2005 Apr;2(4):e112. Epub 2005 Apr 26.

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration.

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  • 1Division of Infectious Disease and Center for AIDS Research, Stanford University, Stanford, California, USA. rkantor@brown.edu

Abstract

BACKGROUND:

The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.

METHODS AND FINDINGS:

To assess the impact of HIV-1 subtype and antiretroviral treatment on the distribution of mutations in protease and reverse transcriptase, a binomial response model using subtype and treatment as explanatory variables was used to analyze a large compiled dataset of non-subtype-B HIV-1 sequences. Non-subtype-B sequences from 3,686 persons with well characterized antiretroviral treatment histories were analyzed in comparison to subtype B sequences from 4,769 persons. The non-subtype-B sequences included 461 with subtype A, 1,185 with C, 331 with D, 245 with F, 293 with G, 513 with CRF01_AE, and 618 with CRF02_AG. Each of the 55 known subtype B drug-resistance mutations occurred in at least one non-B isolate, and 44 (80%) of these mutations were significantly associated with antiretroviral treatment in at least one non-B subtype. Conversely, of 67 mutations found to be associated with antiretroviral therapy in at least one non-B subtype, 61 were also associated with antiretroviral therapy in subtype B isolates.

CONCLUSION:

Global surveillance and genotypic assessment of drug resistance should focus primarily on the known subtype B drug-resistance mutations.

PMID:
15839752
[PubMed - indexed for MEDLINE]
PMCID:
PMC1087220
Free PMC Article
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