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Cutis. 2005 Mar;75(3):167-8.

Inflammatory actinic keratoses secondary to systemic chemotherapy.

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  • 1Division of Dermatology, Department of Medicine, Cooper Health System, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.


Traditionally, systemic 5-fluorouracil has been associated with a reaction that produces inflammation of preexisting and subclinical actinic keratoses (AKs). We report a case of an inflammatory reaction occurring in AKs secondary to the use of doxorubicin. The cutaneous reaction was successfully managed with the application of high-potency topical steroids over the body and with pain management. When the doxorubicin was discontinued and another agent (paclitaxel) was instituted, the cutaneous reaction gradually diminished.

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