J Infect Dis. 2005 May 15;191(10):1623-30. Epub 2005 Apr 13.

B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area.

Dorfman JR, Bejon P, Ndungu FM, Langhorne J, Kortok MM, Lowe BS, Mwangi TW, Williams TN, Marsh K.

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Kenya Medical Research Institute, Wellcome Trust Research Laboratories, Kilifi, Kenya. jeffreydorfman@yahoo.com

Abstract

To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigen-specific memory B cells from donors in an area where malaria is endemic. We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens: the C-terminal portion of merozoite surface protein 1 (MSP1(19)), apical membrane antigen 1 (AMA1), and the cysteine-rich interdomain region 1 alpha (CIDR1 alpha ) of a protein from the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. These data are the first to be generated on memory B cells in children who are in the process of acquiring antimalarial immunity, and they reveal defects in B cell memory to P. falciparum antigens. Compared with the results for tetanus toxoid, more donors who were positive for antibody to AMA1 and CIDR1 alpha were negative for memory B cells. These data imply that some exposures to malaria do not result in the establishment of stable populations of circulating antigen-specific memory B cells, suggesting possible mechanisms for the short-lived nature of many anti-malarial antibody responses.

PMID:: 15838788; [PubMed - indexed for MEDLINE]

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B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area.

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