Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Rheumatol. 2005 May;17(3):257-64.

Randomized controlled trials in vasculitis associated with anti-neutrophil cytoplasmic antibodies.

Author information

  • 1The University of Heidelberg.

Abstract

PURPOSE OF REVIEW:

To review three major randomized clinical trials in forms of vasculitis associated with anti-neutrophil cytoplasmic antibodies.

RECENT FINDINGS:

The design features, results, and context of the Cyclophosphamide versus Azathioprine for the Remission Phase of Vasculitis, Non-renal AAV alternatively treated with Methotrexate, and Wegener Granulomatosis Etanercept Trial are reviewed.

SUMMARY:

Until recently, therapies for Wegener granulomatosis and microscopic polyangiitis have been based primarily on a relatively small number of nonrandomized studies. During the past 18 months, three randomized, controlled trials (one double-blinded) have been performed in vasculitis associated with anti-neutrophil cytoplasmic antibodies. Careful comparisons of the results of these trials yield insights into new standards of care for vasculitis associated with anti-neutrophil cytoplasmic antibodies. This paper summarizes the designs of these three trials; highlights their principal conclusions, strengths, and shortcomings; and distills from their results several recommendations on major questions related to the therapy of vasculitis associated with anti-neutrophil cytoplasmic antibodies.

PMID:
15838233
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk