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Adv Protein Chem. 2005;70:37-78.

The structure of alpha-helical coiled coils.

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  • 1Max-Planck-Institute for Developmental Biology, D-72076 Tübingen, Germany.


alpha-Helical coiled coils are versatile protein domains, supporting a wide range of biological functions. Their fold is probably better understood than that of any other protein; indeed, uniquely among folds, their structure can be computed from a set of parametric equations. Here, we review the principles of coiled-coil structure, the determinants of their folding and stability, and the diversity of structural forms they assume.

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