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Lancet. 2005 Apr 16-22;365(9468):1415-28.

The metabolic syndrome.

Author information

  • 1Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA. Robert.Eckel@UCHSC.edu

Abstract

The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.

Comment in

  • The metabolic syndrome. [Lancet. 2005]
  • The metabolic syndrome. [Lancet. 2005]
PMID:
15836891
[PubMed - indexed for MEDLINE]
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