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Genome Biol. 2005;6(4):R38. Epub 2005 Mar 31.

Derivation of genetic interaction networks from quantitative phenotype data.

Author information

  • 1Institute for Systems Biology, 1441 N, 34th Street, Seattle, WA 98103, USA. bdrees@u.washington.edu

Abstract

We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.

PMID:
15833125
[PubMed - indexed for MEDLINE]
PMCID:
PMC1088966
Free PMC Article

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