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Diagn Cytopathol. 2005 May;32(5):288-91.

A case of uterine adenomyoma with bizarre smooth muscle cells mimicking leiomyosarcoma.

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  • 1Department of Pathology, Showa University Northern Yokohama Hospital, Kanagawa, Japan. yomareko@cmed.showa-u.ac.jp

Abstract

We report a case of adenomyoma of the uterus that was cytologically difficult to distinguish from leiomyosarcoma. Examination of a uterine cervical smear revealed numerous spindle cells that were present in cell clusters or as isolated cells. These cells contained nuclei that were oval-shaped/elongated with nucleoli and delicate wispy cytoplasm. Large and bizarre nuclei were also identified. Based on these cytological findings leiomyosarcoma was considered: however, this diagnosis remained uncertain because of the absence of mitosis and/or necrotic substance. Histologically, we recognized leiomyomatous smooth muscle cells growing in a solid pattern and intermingled with endometrial-type glands. Moreover, bizarre smooth muscle cells were observed in the surface layer of the tumor. These observations suggest that for a diagnosis of uterine leiomyosarcoma the presence of mitosis and/or necrosis is important in addition to nuclear atypia.

Copyright 2005 Wiley-Liss, Inc.

PMID:
15830358
[PubMed - indexed for MEDLINE]
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