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Transfus Med Rev. 2005 Jan;19(1):45-57.

Human blood group genes 2004: chromosomal locations and cloning strategies.

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  • 1Transfusion Medicine Program, Depatment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.


Of the 29 human blood group system genes, 27 have been localized to 14 autosomes and 2 have been assigned to the X chromosome. It is remarkable that 28 of the 29 system genes have now been localized to a single cytogenetic band on a specific chromosome. In this review, we summarize the chromosomal locations and cloning strategies used for those genes encoding blood group systems. We highlight such information about the 3 most recently defined blood group systems (I, GLOB, and GIL). In addition, we provide new information about 2 older blood group systems (SC and RAPH) whose polymorphisms have been defined in cloned genes.

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