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Transfus Med Rev. 2005 Jan;19(1):45-57.

Human blood group genes 2004: chromosomal locations and cloning strategies.

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  • 1Transfusion Medicine Program, Depatment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.

Abstract

Of the 29 human blood group system genes, 27 have been localized to 14 autosomes and 2 have been assigned to the X chromosome. It is remarkable that 28 of the 29 system genes have now been localized to a single cytogenetic band on a specific chromosome. In this review, we summarize the chromosomal locations and cloning strategies used for those genes encoding blood group systems. We highlight such information about the 3 most recently defined blood group systems (I, GLOB, and GIL). In addition, we provide new information about 2 older blood group systems (SC and RAPH) whose polymorphisms have been defined in cloned genes.

PMID:
15830327
[PubMed - indexed for MEDLINE]
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