Autoimmun Rev. 2005 Mar;4(3):123-9.

Statins and autoimmune diseases.

Gurevich VS, Shovman O, Slutzky L, Meroni PL, Shoenfeld Y.

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Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel-Hashomer, Israel.

Abstract

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

PMID:: 15823497; [PubMed - indexed for MEDLINE]

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Statins and autoimmune diseases.

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