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1: Autoimmun Rev. 2005 Mar;4(3):123-9.Click here to read Links

Statins and autoimmune diseases.

Gurevich VS, Shovman O, Slutzky L, Meroni PL, Shoenfeld Y.

Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel-Hashomer, Israel.

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

PMID: 15823497 [PubMed - indexed for MEDLINE]

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