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Clin Exp Rheumatol. 1992 May-Jun;10(3):293-6.

New aspects of HLA: perspectives for rheumatoid arthritis.

Author information

  • Laboratoire d'Immunogénétique Moléculaire, Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, Paris, France.


The association of several HLA class II alleles with genetic susceptibility to rheumatoid arthritis (RA) suggests a model in which a three-dimensional conformation of the DR molecule represents the key disease susceptibility element. However, recently found new genes of the HLA-D region may contribute additionally to the susceptibility in particular of genes coding for proteases and transporter channels. Since expression of the class II molecule is a common feature of the autoimmunity process, regulatory polymorphisms of the class II genes may influence the antigen-presenting capacity of the cells. The role of the invariant chain, a 31 kD protein associated with the alpha beta complex, is emphasized in antigen presentation and may provide new insights into the pathogenesis and therapy of autoimmune rheumatoid arthritis.

[PubMed - indexed for MEDLINE]
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