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Clin Exp Rheumatol. 1992 May-Jun;10(3):293-6.

New aspects of HLA: perspectives for rheumatoid arthritis.

Author information

  • Laboratoire d'Immunogénétique Moléculaire, Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, Paris, France.

Abstract

The association of several HLA class II alleles with genetic susceptibility to rheumatoid arthritis (RA) suggests a model in which a three-dimensional conformation of the DR molecule represents the key disease susceptibility element. However, recently found new genes of the HLA-D region may contribute additionally to the susceptibility in particular of genes coding for proteases and transporter channels. Since expression of the class II molecule is a common feature of the autoimmunity process, regulatory polymorphisms of the class II genes may influence the antigen-presenting capacity of the cells. The role of the invariant chain, a 31 kD protein associated with the alpha beta complex, is emphasized in antigen presentation and may provide new insights into the pathogenesis and therapy of autoimmune rheumatoid arthritis.

PMID:
1582076
[PubMed - indexed for MEDLINE]
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