Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuron. 2005 Apr 7;46(1):103-16.

Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation.

Author information

  • 1Laboratory of Perception and Memory, Pasteur Institute, Centre National de la Recherche, Scientifique (URA 2182), 75015 Paris Cedex, France.

Abstract

The first-order sensory relay for olfactory processing, the main olfactory bulb (MOB), retains the ability to acquire new interneurons throughout life. It is therefore a particularly appropriate region for studying the role of experience in sculpting neuronal networks. We found that nostril closure decreased the number of newborn granule cells in the MOB, the complexity of their dendritic arborization, and their spine density, without affecting the preexisting population of granule cells. Accordingly, the frequency of miniature synaptic inhibitory events received by mitral cells was reduced. However, due to a compensatory increase in newborn granule cell excitability, action potential-dependent GABA release was dramatically enhanced, thus counteracting the reduction in spine density and leading to an unaltered synchronization of mitral cell firing activity. Together, this study reveals a unique form of adaptive response brought about exclusively by the cohort of newborn cells and used to maintain normal functioning of the MOB.

PMID:
15820697
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk