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Neuron. 2005 Apr 7;46(1):1-2.

Antidepressants and the monoamine masquerade.

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  • 1Department of Neurology, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA.


Neurotransmitter transporters have long been known to recognize related compounds as substrates, resulting in the accumulation and release of so-called "false transmitters." In this issue of Neuron, Zhou et al. show that when serotonin levels are elevated by inhibition of either serotonin reuptake or of monoamine oxidase, dopamine neurons accumulate serotonin. The results suggest that release of serotonin by dopamine neurons may contribute to the effects of multiple major classes of antidepressants.

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