Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Psychiatr Scand. 2005 May;111(5):331-40.

The effectiveness of psychological treatments for treatment-resistant depression: a systematic review.

Author information

  • 1Psychotherapy Evaluation Research Unit, Tavistock Centre, London, UK. susan@mcpherson.org.uk

Abstract

OBJECTIVE:

A systematic review of all studies (controlled and uncontrolled) to evaluate psychological interventions with treatment-resistant depression.

METHOD:

A systematic search to identify studies evaluating a psychological intervention with adults with a diagnosis of major depressive disorder who had not responded to at least one course of antidepressant medication.

RESULTS:

Twelve studies met inclusion criteria, of which four were controlled and eight uncontrolled. Treatment effect sizes were computable for four studies and ranged from 1.23 to 3.10 with a number of better quality studies demonstrating some improvements in patients following a psychological intervention.

CONCLUSION:

Psychological treatments for depression are commonly delivered and often recommended following the failure of medication. The paucity of evidence for their effectiveness in these situations is a significant problem. There is a need for studies with a strong controlled design investigating the effectiveness of psychological treatments for patients with treatment-resistant depression.

Copyright Blackwell Munksgaard 2005.

PMID:
15819726
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing Icon for PubMed Health
    Loading ...
    Write to the Help Desk