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    Drugs. 2005;65(6):809-25.

    Peginterferon-alpha-2a (40kD): a review of its use in the management of patients with chronic hepatitis B.

    Robins GW, Scott LJ, Keating GM.

    Source

    Adis International Limited, Auckland, New Zealand. demail@adis.co.nz

    Abstract

    Subcutaneous peginterferon-alpha-2a (40kD) [Pegasys] is an effective and reasonably well tolerated treatment for the management of patients with hepatitis B e antigen (HBeAg)-negative or -positive chronic hepatitis B. It was significantly more effective than lamivudine monotherapy at inducing sustained virological response and ALT normalisation in both HBeAg-negative and -positive patients. Notably, the addition of lamivudine to peginterferon-alpha-2a (40kD) conferred no additional benefit versus peginterferon-alpha-2a (40kD) monotherapy. Moreover, in HBeAg-positive patients significantly more peginterferon-alpha-2a (40kD) recipients experienced HBeAg seroconversion than lamivudine recipients. The position of peginterferon-alpha-2a (40kD) relative to other treatment options remains to be fully determined. In the meantime, this agent appears to be a valuable new option for the management of patients with HBeAg-negative or -positive chronic hepatitis B.

    PMID:
    15819595
    [PubMed - indexed for MEDLINE]

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