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Phys Med Biol. 2005 Apr 21;50(8):1837-50. Epub 2005 Apr 6.

Attenuation correction for small animal PET tomographs.

Author information

  • 1David Geffen School of Medicine at UCLA, Crump Institute for Molecular Imaging, University of California, Los Angeles, 90095, USA. plchow@mednet.ucla.edu

Abstract

Attenuation correction is one of the important corrections required for quantitative positron emission tomography (PET). This work will compare the quantitative accuracy of attenuation correction using a simple global scale factor with traditional transmission-based methods acquired either with a small animal PET or a small animal x-ray computed tomography (CT) scanner. Two phantoms (one mouse-sized and one rat-sized) and two animal subjects (one mouse and one rat) were scanned in CTI Concorde Microsystem's microPET Focus for emission and transmission data and in ImTek's MicroCAT II for transmission data. PET emission image values were calibrated against a scintillation well counter. Results indicate that the scale factor method of attenuation correction places the average measured activity concentration about the expected value, without correcting for the cupping artefact from attenuation. Noise analysis in the phantom studies with the PET-based method shows that noise in the transmission data increases the noise in the corrected emission data. The CT-based method was accurate and delivered low-noise images suitable for both PET data correction and PET tracer localization.

PMID:
15815099
[PubMed - indexed for MEDLINE]
PMCID:
PMC1479306
Free PMC Article

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