Nat Med. 2005 Apr;11(4 Suppl):S45-53.

Mucosal immunity and vaccines.

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Department of Medical Microbiology & Immunology and Göteborg University Vaccine Research Institute, Göteborg University, SE-405 30 Göteborg, Sweden. jan.holmgren@microbio.gu.se

Abstract

There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders.

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