Your browser version may not work well with NCBI's Web applications. More information here...
1: Bioorg Med Chem Lett. 2005 Apr 15;15(8):2027-32.Click here to read Links

Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNgamma.

Tseng HY, Wu SH, Huang WH, Wang SF, Yang YN, Mahindroo N, Hsu T, Jiaang WT, Lee SJ.

Division of Biotechnology and Pharmaceutical Researches, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County, Taiwan, ROC.

A series of benzothiazolium compounds were identified as novel classes of inhibitors of nitric oxide production in a cell culture system. They exhibited approximately 1600 folds potency with IC(50) at approximately 50nM to several microM as compared to IC(50) 88.4microM of l-NMMA, a known inhibitor of nitric oxide synthase. The mechanistic studies suggest that decreased iNOS protein synthesis and mRNA transcription, at least in part, were related to the inhibitory activity of effective benzothiazolium compounds. The correlation of in vivo and in vitro activities using mouse paw edema model was also demonstrated.

PMID: 15808462 [PubMed - indexed for MEDLINE]

Patient Drug Information